研究兴趣

Regulation of actin dynamics and analysis of genomic influences on actin 函数.

阐明结构, dynamics and 函数s of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications.

Fibrosis; Scarring; Protein degradation; ubiquitin; integrins; cytoskeleton; patient-derived 模型系统

• Extracellular kinase signaling
• Extracellular chaperone 函数 
• Targeting extracellular signaling networks in urological cancers

Molecular mechanisms of protein transport and localization in retinal neurons; mechanisms of retinal degenerative diseases

Mitochondrial biology, stress signaling and aging-related degenerative diseases.

Epigenetic regulation of chromatin, 混合系白血病, 结构生物学, 酶学, 生物物理化学, 合理的药物设计

F-type ATP synthases; bioenergetics of pathogenic bacteria; enzymology; structural biology, 膜蛋白功能.

Chromosomal DNA replication origins (location, 定时和调节), replication fork integrity and checkpoint regulation, genomic instability and chromosome fragility in both the yeast and human genome

My research includes studies of the role of microRNA in development of leukemia.

Gene expression in development and disease, RNA pol II regulation, homeobox genes, prolyl isomerases

Vacuolar H+ATPases (structure, 函数, 装配与调节), 细胞pH稳态, 细胞应激反应, 蛋白质排序, 基因组学, 酵母是一个模型系统

My research is primarily focused on defining the role of SHIP1 in immunity, 肥胖, stem cell biology and cancer. This research has revealed that SHIP1 is at the nexus of signaling pathways that regulate: (1) hematopoietic and mesenchymal stem cell homeostasis, (2) terminal differentiation of myeloid cells, (3) acute BM graft rejection, (4) survival of T cells in the small intestine and (5) survival of hematologic cancer cells. More recently we developed SHIP1 and pan-SHIP1/2 inhibitors and showed they can expand stem cells in vivo, 逆转肥胖, eradicate certain cancers and boost tumor immunity. We are also attempting to better understand what LRBA does in immune cells. LRBA is a scaffold protein that coordinates intracellular vesicle trafficking with receptor signaling.

Visual transduction, Gene Expression, Membrane proteins

RNA polymerase I transcription (structure, 组装, 监管), 核仁的生物学, macromolecular architecture, 交联, 蛋白质组学, 生物信息学, 建模, 分子遗传学, 生物化学, 模型系统

癌症生物学, 细胞信号传导, the role of actin cytoskeleton in tumor progression, 小鼠癌症模型

癌症系统生物学, 生物信息学, big data and survival prediction analyses, predictive and personalized medicine, computational genome and 转录组 biology, 非b DNA结构, RNA, DNA杂交, R-loops, G-quadruplexes, ncRNAs, clinical biomarker discovery and validation

Protein engineering, design, and folding

• Genetic, epigenetic, and neuroanatomical basis of neurological and psychiatric disorders
• Basal ganglia and cerebellar circuitry in normal and disease states
• Neural-immune and gut-brain interactions
• Machine learning approaches for biomarker discovery
• Next generation sequencing for multiomic data analysis (genome, 转录组, 微生物组, methylome) 

Role of molecular chaperone Hsp90 in cancers

Kidney Cancer, Bladder Cancer, Breast Cancer

Tuberous Sclerosis Complex syndrome (TSC)

Birt-Hogg-Dubé syndrome (BHD)

Genes and Viruses Predisposing to Autoimmunity, 遗传学, 细胞凋亡, 内源性逆转录病毒, Transaldolase

Neurogenesis; Retinal Progenitor Cells Specification and Proliferation; Genetic Control of Stem Cell Identity and Maintenance; Disease Genes Analysis in Drosophila

Understanding how muscle cells organize their actin cytoskeleton into efficient contractile units, 使用的组合 在体外 生物化学, and analysis of cultured muscle cells and genetic models C. 线虫 和斑马鱼.

• Regulation of actin filament polymerization
• Mechanisms of actin-microtubule crosstalk
• Role of actin and microtubules in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS).
• Single-molecule super-resolution microscopy techniques (i.e. 雨、雨、雨).

Ribonucleoprotein 组装 and biogenesis; mitochondrial RNA import, 信使rna降解, 细胞周期控制

Mammalian retinal stem cells formation; molecular mechanism of retinal cell fate decisions; vascular development in the CNS; using cell replacement therapy to heal the blinded eye.

Structure and Mechanism of Membrane Bound Transport Proteins

The molecular basis of retinal stem cell formation; regulating retinal stem/progenitor cell proliferation; using retinal stem/progenitor cells to heal the injured or degenerating retina.