研究项目和附属机构
研究兴趣
Neuroimmunology: Regulation of genes involved in innate immunity and chronic inflammation in the CNS
Neurovirology: CNS-specific mechanisms involved in viral neurotropis, 对于, 持久性, 炎症和抗病毒状态.
Neurodegeneration: Neuron-specific regulation of apoptotic genes by NF-kappa B and mechanisms regulating CNS-specific mitochondrial bioenergetics.
协会/会员
教育
研究抽象
Regulation of virus-induced innate immunity.
Pattern recognition receptors (PRRs) expressed on cells are important for detecting pathogen-associated molecular patterns (PAMPS) during virus infections and promoting innate inflammatory immune responses to the virus. While these responses are essential for eradication of a virus from the host, these responses may lead to extensive immunopathogenic tissue damage if not properly regulated. Among the myriad of proteins that regulate these responses in cells, the most critical is the protein tyrosine phosphatase SHP-1. 像这样, SHP-1 has been shown to be a key negative regulator of signaling intensiity through both PRRs and proinflammatory cytokine receptors expressed on cells. Our current goal is to determine the mechanisms by which SHP-1 appropriately controls the biological activities of these receptors during pathogen-induced inflammatory responses in various tissues and how these controls might be disrupted during severe inflammatory diseases particularly within the central nervous system.
选择引用
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马萨,P.T.惠特尼，L.W.吴，C.罗普卡，S.L.Jarosinski, K.W. 1999 A mechanism for selective induction of 2’-5’ oligoadenylate synthetase, 抗病毒的状态, but not MHC class I genes by interferon-beta in neurons. J. Neurovirol.5:161-171.
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